Elucidating isoniazid resistance using molecular

The results show that the hydrogen bonding and van der Waals forces play major roles in stabilizing the 1:1 INH-SOD complex.

After addition of INH during the range of the experiment, the conformation and microenvironment of Cu/Zn-SOD are changed, but the activity of Cu/Zn-SOD is not changed. Isoniazid (INH) is the foremost first-line antibiotic used to treat TB, which continues to be the cornerstone of all antituberculosis regimens and remains the only agent recommended for tuberculosis chemoprophylaxis for children [].

ATDH can be fatal if it is not recognised at an early stage, after which therapy should be interrupted timely.

Moreover, ATDH has a negative impact on therapy adherence, decreases success rates of treatment and eventually increases treatment failure, relapse or the emergence of drug resistance.

shows the fluorescence spectra of Cu/Zn-SOD upon the addition of INH.

Synchronous fluorescence measurement provides information about the molecular microenvironment in the vicinity of the fluorophore functional groups [, the fluorescence intensities of tryptophan residue and tyrosine residue decreased with the increase of the concentration of INH.

The maximum emission wavelength of tyrosine residues does not undergo a significant shift in the investigated concentration range.

The occurrence of hepatotoxicity related to INH has been well-defined [].

To better understand the protective mechanism of SOD, the interaction between SOD and INH should be investigated.

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