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The signal disruption could not be corrected by supplementation with any coactivators known at the time, nor was the absent coactivator protein characterized, which left some in the field unconvinced that a mutant coactivator would explain the mechanism of androgen resistance in CAIS or PAIS patients with a normal AR gene.
A genetic male conceived by a man with AIS would not receive his father's X chromosome, thus would neither inherit nor carry the gene for the syndrome.
This combination functions as a transcription complex to turn on androgen gene expression.
Thus the AR activates these genes to mediate the effects of androgens in the human body, including the development and maintenance of the male sexual phenotype and generalized anabolic effects. AIS is divided into three categories that are differentiated by the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia are that of a normal female; mild androgen insensitivity syndrome (MAIS) is indicated when the external genitalia are that of a normal male, and partial androgen insensitivity syndrome (PAIS) is indicated when the external genitalia are partially, but not fully, masculinized.
Target genes are transcribed (m RNA) and translated into proteins.
The effects that androgens have on the human body (virilization, masculinization, anabolism, etc.) are not brought about by androgens themselves, but rather are the result of androgens bound to androgen receptors; the androgen receptor mediates the effects of androgens in the human body.
However, given the scarcity of fertile AIS men and low incidence of AR mutation, the chances of this occurrence are small.
The phenotype of such an individual is a matter of speculation; as of 2010, no such documented case has been published.
Middle, the eight exons are separated by introns of various lengths.
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Phosphorylation (P) occurs before or after steroid binding.
The AR translocates to the nucleus where dimerization, DNA binding, and the recruitment of coactivators occur.